Verified Document

68Ga -Dotatoc In Imaging Neuroendocrine Tumors Term Paper

A cohort of approximately one hundred participants recently diagnosed and not yet treated for neuroendocrine tumors will eventually be selected for this study, providing an adequate sample size to produce significant validity, reliability, and generalizability (Gabriel et al., 2007). A control group of approximately twenty-five individuals recently given negative results on conventional scintigraphy and/or dedicated CT diagnostic measures for neuroendocrine tumors will also be included in this study. All study participants will undergo imaging/diagnostic testing for neuroendocrine tumors using each of the three target methodologies -- [68Ga]-DOTATOC-based PET imaging, conventional scintigraphy, and dedicated CT (111ln-octreotide scintigraphy), with all tests completed on each patient within a four-day timeframe and all testing for the study completed in a three-month period. Follow-up documentation of treatments, neuroendocrine tumor diagnosis confirmation or rejection using histopathology, CT and MRI, and an ultimate determination of neuroendocrine tumor at the time of initial testing will also be conducted in order to validate the findings of initial diagnostic outcomes from the methodologies employed in the research, with follow-up examinations occurring at three weeks and again at six weeks after initial testing (Buchmann et al., 2007; Gabriel et al., 2007). Several local facilities have the capabilities to perform all necessary tests as described herein, and will be selected based on cost, availability, and proximity to participants (to reduce rates of attrition). Images...

Comparisons of outcomes in the primary research group will serve as the base measure for the accuracy and efficacy of the various diagnostic measures investigated. The control group will be used to provide greater potential evidence of false positive emergence in the tests utilized, and could also demonstrate inaccuracy in previous clinical diagnostics.
References

Buchmann, I., Hense, M., Engelbrecht, S., Eisenhut, M…. & Haberkorn, U. (2007). Comparison of 68Ga-DOTATOC PET and 111In-DTPAOC (Octreoscan) SPECT in patients with neuroendocrine tumours. European Journal of Nuclear Medicine & Molecular Imaging 34(10): 1617-26.

Gabriel, M., Decristoforo, C., Kendler, D., Dobrozemsky, G…. & Virgolini, I. (2007). Ga-DOTA-Tyr3-Octreotide PET in Neuroendocrine Tumors: Comparison with Somatostatin Receptor Scintigraphy and CT. Journal of Nuclear Medicine48(4): 508-18.

Hofmann, M., Maecke, H., Borner, a., Weckesser, E…. & Meyer, G. (2001). Biokinetics and imaging with the somatostatin receptor PET radioligand 68Ga-DOTATOC: preliminary data. Molecular Medicine & Molecular Imaging 28(12): 1751-1757.

Poeppel, T., Binse, I., Petersenn, S., Lahner, H…. & Boy, C. (2011). 68Ga-DOTATOC versus 68Ga-DOTATATE PET/CT in functional imaging of neuroendocrine tumors. Journal of Nuclear…

Sources used in this document:
References

Buchmann, I., Hense, M., Engelbrecht, S., Eisenhut, M…. & Haberkorn, U. (2007). Comparison of 68Ga-DOTATOC PET and 111In-DTPAOC (Octreoscan) SPECT in patients with neuroendocrine tumours. European Journal of Nuclear Medicine & Molecular Imaging 34(10): 1617-26.

Gabriel, M., Decristoforo, C., Kendler, D., Dobrozemsky, G…. & Virgolini, I. (2007). Ga-DOTA-Tyr3-Octreotide PET in Neuroendocrine Tumors: Comparison with Somatostatin Receptor Scintigraphy and CT. Journal of Nuclear Medicine48(4): 508-18.

Hofmann, M., Maecke, H., Borner, a., Weckesser, E…. & Meyer, G. (2001). Biokinetics and imaging with the somatostatin receptor PET radioligand 68Ga-DOTATOC: preliminary data. Molecular Medicine & Molecular Imaging 28(12): 1751-1757.

Poeppel, T., Binse, I., Petersenn, S., Lahner, H…. & Boy, C. (2011). 68Ga-DOTATOC versus 68Ga-DOTATATE PET/CT in functional imaging of neuroendocrine tumors. Journal of Nuclear Medicine 52(12): 1864-70.
Cite this Document:
Copy Bibliography Citation

Related Documents

68 GA Dota TOC Radiopharmaceutical
Words: 1828 Length: 6 Document Type: Research Proposal

Ga DOTA TOC Radio Pharmaceutical Neuroendocrine tumors (NET) are neoplasms characterized by tissue immunoreactivity for neuroendocrine differentiation markers, appearance as a small mass that can be off white to yellow often in submucosa and prevalence throughout the body but typically found in the intestine or lungs (Oberg2011). The tumors can be malignant and are typically detected through hormone markers in a first diagnosis (Arnold 2003). Because of the diffuse nature of

Magnetic Resonance Imaging History of MRI the
Words: 1166 Length: 3 Document Type: Essay

Magnetic Resonance Imaging History of MRI The Magnetic Resonance Imaging (MRI) was first tested in Budapest Hungry in 1882. Later in 1937, Professor Isidor Rabi of Columbia University assembled a Nuclear Magnetic Resonance. This tool was effective because it could absorb and emit radio waves after exposure to a strong magnetic field. Professor Carr Herman produced one-dimensional MRI imaging processor in 1952. The nuclear powered NMR was instrumental in experiments developed to

Role of Radiodiagnostic Imaging in
Words: 1581 Length: 6 Document Type: Term Paper

Certainly, it must be stated that more study is needed and worth pursuing in this diagnostic method in forensics. References Bisset, R. et al. (2002) Postmortem examinations using magnetic resonance imaging: four-year review of a working service BMJ 2002;324:1423-1424 (15 June) Online available: http://bmj.bmjjournals.com/cgi/content/full/324/7351/1423 Post Mortem Magnetic Resonance Imaging (MRI) (2005) http://www.forensicmed.co.uk/developments.htm Alderstein M.E., Peringa J., van der Hulst V.P.M, Blaauwgeers H.L.G., van Lith J.M.M. (2003), 'Perinatal mortality: clinical value of post-mortem magnetic

Astrocytic Tumors Brain Tumor Is
Words: 2607 Length: 10 Document Type: Term Paper

Using MRS chemical composition of the tumor and the metabolite intensities can also be ascertained along with the morphological characterisitcs. Thus MRI provides better information which is useful in grading the tumor. For grade 4 astrocytoma's spectroscopic studies reveal high Cho, high lipid, high lactate and low NAA values. However, the MRI testing is time consuming (40 to 90 minutes) and is problematic for claustrophobic patients. [eMedicine] Biopsy of

Brain Tumors Originate From the
Words: 1334 Length: 4 Document Type: Research Paper

The other symptom is that a victim will experience a change in mental capability or individual's distinctive characters. Either the patient or his/her close associates can identify the symptoms independently. The final symptoms are those that helps in location of the tumor as an effect of the pressure exerted on the surrounding areas. They include a large number of symptoms but the locally noted include the weakening of different

Sign Up for Unlimited Study Help

Our semester plans gives you unlimited, unrestricted access to our entire library of resources —writing tools, guides, example essays, tutorials, class notes, and more.

Get Started Now